Research Information

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To assess the detoxification efficacy, these medicines were subjected to animal trials and thoroughly tested upon animals of various species for different intoxicants such as :

Alcohol:

At first, these medicines were tested for addiction of alcohol in monkeys. To begin with, experimental neurosis was developed in monkeys by subjecting them to neurotogenic trauma.They were served food; and a rubber snake was concealed in their food. While eating, they sighted the rubber snake in their food.They got agitated and refused to eat. By virtue of repetition of this process, neurosis developed in them. Then, they were given 1.5 ml/kg (body weight) alcohol. This dose of alcohol disintegrated the neurotic complex. Neurotic monkeys, when mildly intoxicated, resumed eating. After experiencing relief from neurotic tension, they preferred taking some alcohol before meals; otherwise, they were unable to take food. Hence, addiction to alcohol developed in them.

These monkeys were divided into two groups. One group was given Detoxin and the other group was given Placebo with following results:

Group treated with
No. of monkeys treated
No. of monkeys resumed eating without alcohol
No. of monkeys resumed eating but less without alcohol
No. of monkeys did not resume
eating
Detoxin
10
8
1
1
Placebo
10
Nil
1
9

Morphine: Acute dependence

This experiment was conducted upon Albino mice. Samples of 60 Albino mice were taken and were given Morphine HCL 20 mg/kg (body weight). About 4 hours later these mice were divided into two groups. One group was given Detoxin and the other one Placebo. After 5 minutes. both groups were given Nalaxone 5 mg/kg (body weight). Following results observed:

Group treated withTotal no. of mice

no withdrawals found in

Rearing occurredJumping, urination, defaecation occurred in
Detoxin302271
Placebo3032727
 

Barbiturates

For this experiment, samples of 20 cats were taken. They were given Sodium Barbital 95 mg/kg (body weight) two times daily and this dose was increased gradually, until the dose level of Sodium Barbital reached to 200 mg/kg in 180 days. Then, these cats were divided into two groups and were deprived of Sodium Barbital. Thereafter, one group was given Detoxin and Placebo was given to the other group. Following results observed:

Group treated withNo. of catsStrong seizures occurred inMild seizures occurred inseizure occurred in
Detoxin1028
Placebo1091
 

Clinical Trial

192 cases of addicts of various types were studied. Directly administering Detoxin to the control group was not considered necessary as Placebo effect gets nullified while testing the potencies. Moreover, each potency of Detoxin can not suit to a person. Had there been placebo effects, each potency of Detoxin would suit. This study of 192 cases was conducted for 1 year. The Observations are as follows:

AGE :

Below 20 yrs.21-30 yrs.31-40 yrs.41-50 yrs.51-60 yrs.Above 60 yrs.
14
72
57
25
17
7

Educational Status :

NilPrimary SchoolJunior High SchoolHigh SchoolIntermediate
3917253229
GraduatePost GraduateProfessionalsMisc.
239135

Profession :

Unemployed

Govt. ServiceAdvocateFarmerDriverHotelBusiness
261843416221
Pvt. ServiceDoctorStudentTechnicalLaborerMisc.
95154434

Marital Status :

UnmarriedMarriedWidowerDivorceeSeparated
2291102742

Addiction :

AlcoholCannabisOpiatesAlcohol, CannabisAlcohol, Opiates
691358159
Alcohol, Diazepam, OpiatesAlcohol, Cannabis, OpiatesOpiates, DiazepamCannabis, Opiates
39115

Relapse :

AlcoholCannabisOpiatesAlcohol, CannabisAlcohol, Opiates
3242633
Alcohol, Diazepam, OpiatesAlcohol, Cannabis, OpiatesOpiates, DiazepamCannabis, Opiates
1216

Relapsed During :

0-3 months3-6 months6-9 monthsAfter 9 months
35211210

Relapsed Due to :

WithdrawalCravingImpotencyFamily TensionCompanyDrug Peddling
343114917

Another separate study was also conducted in which cases of smoking/chewing tobacco were studied; though, some of them used to take occasionally other intoxicants or were addicted to them such as alcohol, cannabis, sedatives, Hypnotics and antidepressent. Details are as follows :

Addiction :

Chewing TobaccoSmokingBoth
9553141

Relapse :

Chewing TobaccoSmokingBoth
191178


Relapsed During :

1st week2-4 week2-3 months3-6 months6-9 monthsAfter 9 months
233621262315

Relapsed Due to :

Did not take medicine properlyUrgeWith-drawlPersuasion by someonecuriosity
19135832
Mental shockno reasonLonelinessDesire to hold some- thing between fingersignorance of the medical instructions
12274618

When they smoked again, they experienced :

AversionUsual tasteMild taste /tastelessness
633744

The persons who got relapsed, started to take quantity/day :

ReducedSameincreased
884313